Select peer-reviewed publications. Research in the field of aging is continuously evolving and improving. 

 

Quercetin:

[1] Cui Z, Zhao X, Amevor FK, Du X, Wang Y, Li D, Shu G, Tian Y, Zhao X. Therapeutic application of quercetin in aging-related diseases: SIRT1 as a potential mechanism. Front Immunol. 2022 Jul 22;13:943321. doi: 10.3389/fimmu.2022.943321. PMID: 35935939; PMCID: PMC9355713.

[2] Deledda A, Giordano E, Velluzzi F, Flore G, Franceschelli S, Speranza L, Ripari P. Mitochondrial Aging and Senolytic Natural Products with Protective Potential. Int J Mol Sci. 2022 Dec 19;23(24):16219. doi: 10.3390/ijms232416219. PMID: 36555859; PMCID: PMC9784569.

[3] Islam MT, Tuday E, Allen S, Kim J, Trott DW, Holland WL, Donato AJ, Lesniewski LA. Senolytic drugs, dasatinib and quercetin, attenuate adipose tissue inflammation, and ameliorate metabolic function in old age. Aging Cell. 2023 Feb;22(2):e13767. doi: 10.1111/acel.13767. Epub 2023 Jan 13. PMID: 36637079; PMCID: PMC9924942.

 

Fisetin:

[4] Yousefzadeh MJ, Zhu Y, McGowan SJ, Angelini L, Fuhrmann-Stroissnigg H, Xu M, Ling YY, Melos KI, Pirtskhalava T, Inman CL, McGuckian C, Wade EA, Kato JI, Grassi D, Wentworth M, Burd CE, Arriaga EA, Ladiges WL, Tchkonia T, Kirkland JL, Robbins PD, Niedernhofer LJ. Fisetin is a senotherapeutic that extends health and lifespan. EBioMedicine. 2018 Oct;36:18-28. doi: 10.1016/j.ebiom.2018.09.015. Epub 2018 Sep 29. PMID: 30279143; PMCID: PMC6197652.

[5] Zhu Y, Doornebal EJ, Pirtskhalava T, Giorgadze N, Wentworth M, Fuhrmann-Stroissnigg H, Niedernhofer LJ, Robbins PD, Tchkonia T, Kirkland JL. New agents that target senescent cells: the flavone, fisetin, and the BCL-XL inhibitors, A1331852 and A1155463. Aging (Albany NY). 2017 Mar 8;9(3):955-963. doi: 10.18632/aging.101202. PMID: 28273655; PMCID: PMC5391241.

[6] Hosseini SS, Ebrahimi SO, Haji Ghasem Kashani M, Reiisi S. Study of quercetin and fisetin synergistic effect on breast cancer and potentially involved signaling pathways. Cell Biol Int. 2023 Jan;47(1):98-109. doi: 10.1002/cbin.11942. Epub 2022 Oct 23. PMID: 36273436.

Resveratrol:

[7] Pyo IS, Yun S, Yoon YE, Choi JW, Lee SJ. Mechanisms of Aging and the Preventive Effects of Resveratrol on Age-Related Diseases. Molecules. 2020 Oct 12;25(20):4649. doi: 10.3390/molecules25204649. PMID: 33053864; PMCID: PMC7587336.

[8] Hosoda R, Nakashima R, Yano M, Iwahara N, Asakura S, Nojima I, Saga Y, Kunimoto R, Horio Y, Kuno A. Resveratrol, a SIRT1 activator, attenuates aging-associated alterations in skeletal muscle and heart in mice. J Pharmacol Sci. 2023 Jun;152(2):112-122. doi: 10.1016/j.jphs.2023.04.001. Epub 2023 Apr 11. PMID: 37169475.

[9] Kohandel Z, Darrudi M, Naseri K, Samini F, Aschner M, Pourbagher-Shahri AM, Samarghandian S. The Role of Resveratrol in Aging and Senescence: A Focus on Molecular Mechanisms. Curr Mol Med. 2023 Jun 2. doi: 10.2174/1566524023666230602162949. Epub ahead of print. PMID: 37278035.

 

Curcumin:

[10] Izadi M, Sadri N, Abdi A, Zadeh MMR, Jalaei D, Ghazimoradi MM, Shouri S, Tahmasebi S. Longevity and anti-aging effects of curcumin supplementation. Geroscience. 2024 Feb 27. doi: 10.1007/s11357-024-01092-5. Epub ahead of print. PMID: 38409646.

[11] Ng TP, Nyunt SZ, Gao Q, Gwee X, Chua DQL, Yap KB. Curcumin-rich curry consumption and life expectancy: Singapore longitudinal ageing study. Geroscience. 2024 Feb;46(1):969-980. doi: 10.1007/s11357-023-00842-1. Epub 2023 Jun 12. PMID: 37306893; PMCID: PMC10828228.

 

Nicotinamide Riboside Chloride (NRC):

[12] Li W, Wang X, Dong Y, Huo Q, Yue T, Wu X, Lu L, Zhang J, Zhao Y, Dong H, Li D. Nicotinamide riboside intervention alleviates hematopoietic system injury of ionizing radiation-induced premature aging mice. Aging Cell. 2023 Nov;22(11):e13976. doi: 10.1111/acel.13976. Epub 2023 Aug 31. PMID: 37650560; PMCID: PMC10652312.

[13] Zhan R, Meng X, Tian D, Xu J, Cui H, Yang J, Xu Y, Shi M, Xue J, Yu W, Hu G, Li K, Ge X, Zhang Q, Zhao M, Du J, Guo X, Xu W, Gao Y, Yao C, Chen F, Chen Y, Shan W, Zhu Y, Ji L, Pan B, Yu Y, Li W, Zhao X, He Q, Liu X, Huang Y, Liao S, Zhou B, Chui D, Chen YE, Sun Z, Dong E, Wang Y, Zheng L. NAD+ rescues aging-induced blood-brain barrier damage via the CX43-PARP1 axis. Neuron. 2023 Nov 15;111(22):3634-3649.e7. doi: 10.1016/j.neuron.2023.08.010. Epub 2023 Sep 7. PMID: 37683629.

[14] Han X, Bao X, Lou Q, Xie X, Zhang M, Zhou S, Guo H, Jiang G, Shi Q. Nicotinamide riboside exerts protective effect against aging-induced NAFLD-like hepatic dysfunction in mice. PeerJ. 2019 Aug 28;7:e7568. doi: 10.7717/peerj.7568. PMID: 31523515; PMCID: PMC6717504.

Berberine:

[15] Yadawa AK, Srivastava P, Singh A, Kesherwani R, Bhoumik S, Kumar R, Arya JK, Rizvi SI. Berberine may provide redox homeostasis during aging in rats. Z Naturforsch C J Biosci. 2023 Apr 17;78(7-8):307-315. doi: 10.1515/znc-2022-0213. PMID: 37053568.

[16] Dang Y, An Y, He J, Huang B, Zhu J, Gao M, Zhang S, Wang X, Yang B, Xie Z. Berberine ameliorates cellular senescence and extends the lifespan of mice via regulating p16 and cyclin protein expression. Aging Cell. 2020 Jan;19(1):e13060. doi: 10.1111/acel.13060. Epub 2019 Nov 26. PMID: 31773901; PMCID: PMC6974710.

[17] Xu Z, Feng W, Shen Q, Yu N, Yu K, Wang S, Chen Z, Shioda S, Guo Y. Rhizoma Coptidis and Berberine as a Natural Drug to Combat Aging and Aging-Related Diseases via Anti-Oxidation and AMPK Activation. Aging Dis. 2017 Dec 1;8(6):760-777. doi: 10.14336/AD.2016.0620. PMID: 29344415; PMCID: PMC5758350.

[18] Wang L, Tang XQ, Shi Y, Li HM, Meng ZY, Chen H, Li XH, Chen YC, Liu H, Hong Y, Xu HH, Liu L, Zhao L, Han WN, Liu X, Zhang Y. Tetrahydroberberrubine retards heart aging in mice by promoting PHB2-mediated mitophagy. Acta Pharmacol Sin. 2023 Feb;44(2):332-344. doi: 10.1038/s41401-022-00956-w. Epub 2022 Aug 10. PMID: 35948750; PMCID: PMC9889783.

Spermidine:

[19] Hofer SJ, Liang Y, Zimmermann A, Schroeder S, Dengjel J, Kroemer G, Eisenberg T, Sigrist SJ, Madeo F. Spermidine-induced hypusination preserves mitochondrial and cognitive function during aging. Autophagy. 2021 Aug;17(8):2037-2039. doi: 10.1080/15548627.2021.1933299. Epub 2021 Jun 9. PMID: 34105442; PMCID: PMC8386697.

[20] Xu TT, Li H, Dai Z, Lau GK, Li BY, Zhu WL, Liu XQ, Liu HF, Cai WW, Huang SQ, Wang Q, Zhang SJ. Spermidine and spermine delay brain aging by inducing autophagy in SAMP8 mice. Aging (Albany NY). 2020 Apr 8;12(7):6401-6414. doi: 10.18632/aging.103035. Epub 2020 Apr 8. PMID: 32268299; PMCID: PMC7185103.

[21] Ueno D, Ikeda K, Yamazaki E, Katayama A, Urata R, Matoba S. Spermidine improves angiogenic capacity of senescent endothelial cells, and enhances ischemia-induced neovascularization in aged mice. Sci Rep. 2023 May 23;13(1):8338. doi: 10.1038/s41598-023-35447-3. PMID: 37221395; PMCID: PMC10205711.

 

Piperine:

[22] Islam MR, Rauf A, Akash S, Trisha SI, Nasim AH, Akter M, Dhar PS, Ogaly HA, Hemeg HA, Wilairatana P, Thiruvengadam M. Targeted therapies of curcumin focus on its therapeutic benefits in cancers and human health: Molecular signaling pathway-based approaches and future perspectives. Biomed Pharmacother. 2024 Jan;170:116034. doi: 10.1016/j.biopha.2023.116034. Epub 2023 Dec 22. PMID: 38141282.

[23] Shoba G, Joy D, Joseph T, Majeed M, Rajendran R, Srinivas PS. Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers. Planta Med. 1998 May;64(4):353-6. doi: 10.1055/s-2006-957450. PMID: 9619120.

Saffron:

[24] El Midaoui A, Ghzaiel I, Vervandier-Fasseur D, Ksila M, Zarrouk A, Nury T, Khallouki F, El Hessni A, Ibrahimi SO, Latruffe N, Couture R, Kharoubi O, Brahmi F, Hammami S, Masmoudi-Kouki O, Hammami M, Ghrairi T, Vejux A, Lizard G. Saffron (Crocus sativusL.): A Source of Nutrients for Health and for the Treatment of Neuropsychiatric and Age-Related Diseases. Nutrients. 2022 Jan 29;14(3):597. doi: 10.3390/nu14030597. PMID: 35276955; PMCID: PMC8839854.

[25] Tseng TH, Chu CY, Huang JM, Shiow SJ, Wang CJ. Crocetin protects against oxidative damage in rat primary hepatocytes. Cancer Lett. 1995 Oct 20;97(1):61-7. doi: 10.1016/0304-3835(95)03964-x. PMID: 7585479.