Quercetin is a flavonoid found in many fruits, vegetables, and plants. It acts as a powerful antioxidant, helping to neutralize harmful free radicals in the body, thereby reducing oxidative stress and inflammation. Quercetin also has potential anti-cancer, anti-viral, and anti-inflammatory properties, and it may support cardiovascular health and immune function.

Fisetin is a flavonoid found in various fruits and vegetables, particularly strawberries and apples. It shares similarities with quercetin in terms of its antioxidant properties and ability to combat inflammation.

When taken together with quercetin, fisetin may complement its effects due to their similar mechanisms of action. Both compounds act as antioxidants, scavenging free radicals and reducing oxidative stress, which is a major contributor to aging and various age-related diseases. Additionally, they may synergistically modulate pathways involved in inflammation, further supporting overall health and well-being.

Berberine is a bioactive compound found in several plants, including goldenseal, barberry, and Oregon grape. Berberine supports cellular health by activating AMP-activated protein kinase (AMPK), a key regulator of cellular energy metabolism and longevity. By promoting AMPK activation, berberine may help improve mitochondrial function, enhance cellular repair mechanisms, and extend lifespan.

Curcumin is a bioactive compound found in turmeric. Amongst many other health benefits, curcumin may support cellular health and longevity by activating certain cellular pathways involved in longevity and promoting autophagy, the body's natural process of removing damaged cells and debris.

Resveratrol is a natural compound found in various plants, including grapes, berries, and peanuts. Resveratrol is believed to support cardiovascular health by promoting healthy blood circulation, reducing inflammation, and protecting against oxidative damage to blood vessels. Additionally, it may have anti-cancer properties, support brain health by promoting cognitive function and protecting against neurodegenerative diseases, and even aid in weight management by enhancing metabolism and fat oxidation. Resveratrol has also been associated with longevity and is thought to activate certain genes involved in longevity pathways.

As cells age, they become less efficient at producing energy and repairing DNA damage, leading to a decline in overall cellular function. By replenishing NAD+ levels, NRC supplementation may help mitigate age-related cellular decline and promote healthy aging.

Contains spermidine. Spermidine is a polyamine compound found in various foods, including wheat germ, soybeans, and certain fruits. Spermidine has been shown to induce autophagy, a cellular process responsible for removing damaged organelles and proteins. Autophagy plays a crucial role in maintaining cellular health and preventing the accumulation of cellular waste, which can contribute to aging and age-related diseases.

Contains the active compound piperine. Piperine has been shown to enhance the absorption of various nutrients and compounds in the body. It does this by inhibiting certain enzymes in the digestive tract that break down these substances, allowing them to remain in the bloodstream for longer periods and increasing their bioavailability. Curcumin has poor bioavailability. Piperine helps address this issue by inhibiting the enzymes responsible for curcumin metabolism in the liver and intestines.

Saffron contains potent antioxidants like crocin, crocetin, safranal, and kaempferol, which help neutralize harmful free radicals in the body. Oxidative stress accelerates cellular damage, contributing to aging and chronic diseases. By neutralizing free radicals, saffron helps reduce this damage, potentially slowing down the visible and internal signs of aging.

(Crocetin in molecular image)